Some Mr. Men and Little Misses are related to eachother, and also have mentioned unseen members too.
- Little Miss Twins — The book is mainly about two twin sisters.
- Little Miss Whoops — Mr. Bump is Miss Whoops's brother.
- Little Miss Chatterbox — Mr. Chatterbox is Miss Chatterbox's brother.
- Mr. Fussy- Mr. Fussy and Mr. Clumsy are cousins.
- Hello, Pizza Express?-Mr. Rush is related to Mr. Busy and Mr. Fussy.
- Mr. Mean-Mr. Mean has a brother whom he only gives coal to.
- Little Miss Princess-Little Miss Princess has a mother and father who are the Queen and King.
- Mr. Chatterbox Loses His Voice — Mr. Chatterbox had a father, a grandfather, and a great grandfather who all wore green hats.
- Little Miss Splendid's Gift- Miss Splendid has cousins in Seatown.
- Hello, Pizza Express?-Miss Chatterbox has an aunt, a cousin, an uncle, and a cousin by marriage who has red hair.
- Paint — Miss Chatterbox had an uncle who couldn't stand still while being painted due to having hiccups.
- Sneezes and Hiccups - Mr. Rude's family appears at the Dillydale Glee Club concert.